Cellular mechanisms facilitating the spreading of Tau pathology in Alzheimer's disease: uptake, release and synaptic cell-to-cell transmission of Tau nano-aggregates in neuronal networks

• Applicant: Susanne Wegmann, Ph.D.
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2012 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 223752619

• Final Report Year: 2016

No abstract available

Publications

• Split-Luciferase assay for tau oligomerization. Tau Symposium at University of Madrid 2014
  Susanne Wegmann
  
• Tau propagation in microfluidic devices. Annual Meeting of Society for Neuroscience 2014
  Shuko Takeda
  
• Neuronal uptake and propagation of a rare phosphorylated high-molecularweight tau derived from Alzheimer’s disease brain. Nature Communications, 6: 8490 (2015)
  Takeda, Shuko; Wegmann, Susanne; Cho, Hansang; DeVos, Sarah L.; Commins, Caitlin; Roe, Allyson D.; Nicholls, Samantha B.; Carlson, George A.; Pitstick, Rose; Nobuhara, Chloe K.; Costantino, Isabel; Frosch, Matthew P.; Müller, Daniel J.; Irimia, Daniel & Hyman, Bradley T.
  
• Formation, release and internalization of stable tau oligomers in cells. Journal of Neurochemistry Vol 139 Issue 6, December 2016, Pages 1163-1174
  Wegmann, Susanne; Nicholls, Samantha; Takeda, Shuko; Fan, Zhanyun & Hyman, Bradley T.