Sensing and intracellular delivery of iron by fungal monothiol glutaredoxins (D05 (B02))

Subject Area Cell Biology
Term from 2012 to 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 192445154
 

Project Description

Monothiol glutaredoxins are central components of cellular iron homeostasis. They are involved in iron uptake regulation, iron trafficking, biogenesis of iron-sulfur proteins, and assembly of proteins with iron centers. How monothiol glutaredoxins fulfil these diverse physiological functions is unclear. To elucidate their molecular function, we will employ cell biological, proteomic, biochemical, and biophysical approaches with the aim to identify new interaction partners and to define the molecular mechanism of these glutaredoxins and of their bound [2Fe-2S] cluster.
DFG Programme Collaborative Research Centres
Subproject of SFB 987:  Microbial Diversity in Environmental Signal Response
Applicant Institution Philipps-Universität Marburg
Project Heads Professor Dr. Roland Lill; Privatdozent Dr. Ulrich Mühlenhoff