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Transcriptional and epigenetic control by Sirtuins in response to stress (01)

Subject Area Cell Biology
Term from 2012 to 2018
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 201348542
 
The project of Renate Voit and Ingrid Grummt (TP01) seeks to understand the transcription-associated mechanisms that safeguard cellular homeostasis. They will use genome-wide approaches to identify novel targets and pathways that are targeted by the NAD+-dependent protein deacetylase SIRT7 and compare the functional impact of stress on SIRT7-associated proteins. In addition, they will explore the molecular mechanisms that prevent unscheduled formation of R-loops, which represent a potential threat to genome stability. The fact that SIRT7 knockout leads to accumulation of R-loops and causes genomic instability will open up new avenues for understanding the role of acetylation in cellular surveillance and damage response pathways.
DFG Programme Collaborative Research Centres
Co-Applicant Institution Deutsches Krebsforschungszentrum (DKFZ)
Project Heads Professorin Dr. Ingrid Grummt; Dr. Renate Voit, until 7/2017
 
 

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