Reproductive and Developmental Impact of Dietary Phytoestrogens

• Antragstellerinnen / Antragsteller: Professor Dr. Patrick Diel; Dr. Clarissa Gerhäuser; Professorin Sabine E. Kulling, Ph.D.
• Fachliche Zuordnung: Ernährungswissenschaften
• Förderung: Förderung von 2012 bis 2016
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 224980381

Phytoestrogens (PE) are a diverse group of plant-derived compounds that mimic mammalian estrogens both structurally and functionally. Some dietary isoflavones such as genistein and daidzein are quite outstanding comparing with others due to their higher level of estrogen receptor-dependent activity and higher concentration in soy food. Therefore these compounds may act as endocrine disruptors (EDs) by perturbing the delicate endocrine balance in vivo and possess adverse effects especially on the reproductive system and other estrogen-sensitive tissues. Exposure to estrogenic substances during critical periods of development can have adverse consequences on differentiating estrogen-sensitive organs. Moreover, human fetuses and neonates can be exposed to high levels of isoflavones if their mothers consume excessive amounts of soy or if they are given soy-based formulas and other soy products marketed specifically for children. Therefore, due attention should be paid on the adverse impacts of dietary PE on health of infants, children and adolescents which are on one hand the group with the higher isoflavone exposure level per Kg body weight on the other hand the individuals with a relative lower sexual-hormone level and a higher exogenous estrogenic substance sensitivity. Up to date, the involvement of dietary PE such as genistein and daidzein in human estrogen-sensitive organs’ development has not been conclusive. Within a coordinated research concept we plan to investigate the influence of dietary PE exposure during critical periods of development. Therefore the impact of PE on the development of the male and female reproductive and hormone sensitive tissues, metabolism and epigenetic modulations will be studied in animal models simulating different exposure scenarios and suitable biomarkers will be identified. In addition molecular mechanisms of PE activity during development will be studied in adapted cell models. To transfer the mechanistically findings on the human situation, serum and blood cells from children consuming soy food (both in China and Germany) will be analyzed with the aim to discover universal biomarkers for dietary PE risk assessment and elucidate the differences of reactions to dietary PE in European and Chinese population groups.

• DFG-Verfahren: Sachbeihilfen