The role of histone acetyltransferase MOF in development and disease (A02)

• Subject Area: Cell Biology
• Term: from 2012 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192904750

The male specific lethal (MSL) complex is an evolutionarily conserved chromatin complex in flies and mammals. However, the role of the MSL2 protein in mammals remains unclear. In order to dissect MSL2 function, we plan to use female mouse embryonic stem cells and neural progenitor cells as an experimental model system. We aim to dissect the interplay of MOF and MSL2 in monoallelic versus biallelic gene expression to study dosage sensitivity of the targets in an allele specific manner. Taken together this proposal will provide novel insights into the allele-specific regulation by the mammalian MSL complex.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 992: Medical Epigenetics (MEDEP) - From Basic Mechanisms to Clinical Applications
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Co-Applicant Institution: Max-Planck-Institut für Immunbiologie und Epigenetik
• Project Head: Professorin Dr. Asifa Akhtar, Ph.D.