Applying new methods for survival monitoring in transplantation medicine
Final Report Abstract
The project successfully evaluated the use of the period analysis method in the area of solid organ transplantation, empirically demonstrated that it allows the calculation of up-to-date long term graft and patient survival estimates in solid organ transplantation outcome research, introduced the relative survival method to the area of transplantation research and used it to quantify surplus mortality among kidney transplant recipient in the United States, calculated up-to-date estimates of 5- and 10-year kidney graft survival estimates for Europe as well as the United States, and provided the first systematic comparison of long term kidney graft survival between Europe and the US. This comparison demonstrated that 1-year kidney graft survival is essentially equal in Europe and the 3 most important ethnic US populations (white, African and Hispanic Americans), but 5- and 10-year kidney graft survival is substantially lower in all 3 US group than in Europe, despite overall slightly more favourable clinical risk profile in the former. The results may suggest that long term care factors, including access and adherence to immunosuppression medication may be important for explaining the observed kidney graft survival differences. The important and highly relevant results of this comparative outcome study received coverage in both the scientifically oriented and mass media. Report in Nature Reviews Nephrology: http://www.nature.com/nrneph/journal/v8/n12/full/nrneph.2012.235.html Report in the Austrian newspaper “Der Standard”: http://derstandard.at/1348285884016/Nierentransplantate-Europa-besser-als-die-USA Reports in other press organs: http://www.nephrologynews.com/articles/print/109074-kidney-transplants-in-europe-last-longer-than-in-us http://www.news-medical.net/news/20121015/Study-evaluates-international-data-on-kidney-transplantation.aspx http://www.sciencedaily.com/releases/2012/10/121012112426.htm http://medicalxpress.com/news/2012-10-kidney-grafts-function-longer-europe.html http://www.rxwiki.com/news-article/kidney-transplants-last-longer-europe-united-states http://www.transplantation-verstehen.de/service/aktuelles.html?article=66533 http://athene.innovations-report.de/html/berichte/studien/kidney_grafts_function_longer_europe_united_states_203741.html
Publications
- Relative survival of transplant patients: quantifying surplus mortality among renal transplant recipients compared with the general population. Transplantation 2011;92:913-7
Gondos A, Brenner H
- From cancer to transplantation: an evaluation of period analysis for calculating up-to-date long-term survival estimates. Am J Epidemiol 2010;172:613-20
Gondos A, Doehler B, Opelz G, et al.
- Period analysis for more up-to-date graft and patient survival estimates in transplantation: an evaluation using united network for organ sharing data. Transplantation 2010;89:580-8
Gondos A, Brenner H
- Kidney graft survival in Europe and the United States: strikingly different long-term outcomes. Transplantation 2013;95:267-74
Gondos A, Dohler B, Brenner H, et al
(See online at https://doi.org/10.1097/TP.0b013e3182708ea8)
