Psoriasis as a Model to Study Adipokine Effects on Inflammation (B05+)

• Subject Area: Dermatology
• Term: from 2013 to 2017
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 209933838

Obesity is associated with enhanced severity and risk of chronic inflammatory diseases such as psoriasis, multiple sclerosis, asthma, rheumatoid arthritis as well as with a reduced therapeutic success in these diseases. However, mechanistic links between alterations in adipose tissues and the dysregulation of immune responses in obesity-associated chronic inflammatory diseases are poorly understood. Project B5 tests the hypothesis that alterations of adipose tissue in obesity are responsible for the obesity-mediated exacerbation of chronic inflammatory diseases, exemplified in the signature disease psoriasis. We also ask whether central players in the pathogenesis of psoriasis, such as TNFalpha, IL-1beta, IL-17, are involved in the functional control of adipose tissue thus supporting the development of obesity.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1052: Obesity Mechanisms
• Applicant Institution: Universität Leipzig
• Project Heads: Privatdozentin Dr. Anja Saalbach; Professor Dr. Jan-Christoph Simon