Dissecting KDEL receptor clustering at the mammalian cell surface in response to cargo binding, internalization and compartmental transport (A06)

• Subject Area: Cell Biology
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 200049484

Receptor cluster formation is a ubiquitous phenomenon in pro- and eukaryotic cells to physically sense cargo/ligand interactions and subsequently translate an exogenous signal into a cellular response. As a mechanistic understanding of the molecular principles underlying these processes is still lacking, the major goal of this project is to combine genetic, biochemical and imaging data with theoretical modelling to dissect the underlying molecular processes and to identify cellular components involved in cargo-induced KDEL-receptor cluster formation, internalization and transport from and to the plasma membrane in yeast and mammalian cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1027: Physical Modelling of Non-Equilibrium Processes in Biological Systems
• Applicant Institution: Universität des Saarlandes
• Project Head: Professor Dr. Manfred Josef Schmitt