Decoding the functional relevance of compartmentally controlled calcium and redox signaling (C04)

• Subject Area: Biophysics
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 200049484

Ionized calcium (Ca2+) and reactive oxygen species (ROS) are two essential second messengers that cross influence eachother. Intracellular, local Ca2+ and ROS levels are tightly controlled by a number of molecular sources and sinks. Using novel genetically encoded detectors and generators of Ca2+ and ROS and theoretical models and predictions, we aim to 1) Trigger and measure subcellular ROS production and determine their influence on redox regulation of SOCE, cellular transcription and programming. 2) Investigate the functional consequences of the localized SOCE and/or redox regulation in healthy neurons and melano-ma cancer cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1027: Physical Modelling of Non-Equilibrium Processes in Biological Systems
• Applicant Institution: Universität des Saarlandes
• Project Heads: Professor Dr. Ivan Bogeski; Professorin Barbara Anne Niemeyer, Ph.D.