The significance of PI3K- and OSR1/Spak-dependent regulation of Klotho/FGF23 and renal phosphate transport for ageing and age-related diseases

• Applicant: Professor Dr. Michael Föller
• Subject Area: Anatomy and Physiology
• Term: from 2012 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 229507342

• Final Report Year: 2016

No abstract available

Publications

• Functional significance of glutamate-cysteine ligase modifier (GOLM) for erythrocyte survival in vitro and in vivo. Cell Death and Differentiation, Vol. 20. 2013, pp. 1350–1358.
  Föller, M.; Harris, I. S.; Elia, A.; John, R.; Lang, F.; Kavanagh, T. J. & Mak, T. W.
  
• Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and caicium-phophate metabolism. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, Issue 9, pp. 1871–1880.
  Fahkri, Hajar; Zhang, Bingbing; Fajol, Abul; Hernando, Nati; Elvira, Bernat; Mannheim, Julia G.; Pichler, Bernd J.; Daniel, Christoph; Amann, Kerstin; Hirao, Atsushi; Haight, Jillian; Mak, Tak W.; Lang, Florian & Föller, Michael
  
• Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology, Vol. 61. 2015, Issue 1, pp. 275-284.
  Lang, Elisabeth; Gatidis, Sergios; Freise, Noemi F.; Bock, Hans; Kubitz, Ralf; Lauermann, Christian; Orth, Hans Martin; Klindt, Caroline; Schuier, Maximilian; Keitel, Verena; Reich, Maria; Liu, Guilai; Schmidt, Sebastian; Xu, Haifeng C.; Qadri, Syed M.; Herebian, Diran; Pandyra, Aleksandra A.; Mayatepek, Ertan; Gulbins, Erich; ... & Lang, Philipp A.
  
• Enhanced FGF23 production in mice expressing PI3 kinase-insensitive GSK3 is normalized by ßblocker treatment. FASEB Journal, Vol. 30. 2016, No. 2, pp. 994–1001.
  Fajol, Abul; Chen, Hong; Umbach, Anja T.; Quarles, L. Darryl; Lang, Horian & Föller, Michael
  
• Janus kinase 3 regulates renal 25-hydroxyvitamin D 1α-hydroxylase expression, calcitriol formation, and phosphate metabolism. Kidney International, Vol. 87. 2015, Issue 4, pp. 728-737.
  Umbach, Anja T.; Zhang, Bingbing; Daniel, Christoph; Fajol, Abul; Velic, Ana; Hosseinzadeh, Zohreh; Bhavsar, Shefalee K.; Thomas Bock, C.; Kandolf, Reinhard; Pichler, Bernd J.; Amann, Kerstin U.; Föller, Michael & Lang, Florian
  
• NfKB-sensitive Orail expression in the regulation of FGF23 release. Journal of Molecular Medicine, Vol. 94. 2016, Issue 5, pp. 557–566.
  Zhang, Bingbing; Yan, Jing; Umbach, Anja T.; Fakhri, Hajar; Fajol, Abul; Schmidt, Sebastian; Salker, Madhuri S.; Chen, Hong; Alexander, Dorothea; Spichtig, Daniela; Daryadel, Arezoo; Wagner, Carsten A.; Föller, Michael & Lang, Florian