The significance of PI3K- and OSR1/Spak-dependent regulation of Klotho/FGF23 and renal phosphate transport for ageing and age-related diseases

• Applicant: Professor Dr. Michael Föller
• Subject Area: Anatomy and Physiology
• Term: from 2012 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 229507342

• Final Report Year: 2016

Final Report Abstract

No abstract available

Publications

• Functional significance of glutamate-cysteine ligase modifier (GOLM) for erythrocyte survival in vitro and in vivo. Cell Death and Differentiation, Vol. 20. 2013, pp. 1350–1358.
  Poller M., Harris I.S., Elia A., John R., Lang F., Kavanagh T.J., Mak T.W.
  
• Checkpoint kinase Chk2 controls renal Cyp27b1 expression, calcitriol formation, and caicium-phophate metabolism. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, Issue 9, pp. 1871–1880.
  Fahkri H., Zhang B., Fajol A., Hernando N., Elvira B., Mannheim J.G., Pichler B., Daniel C., Amann K., Hirao A., Haight J., Mak T.W., Lang F., Foller M.
  
• Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology, Vol. 61. 2015, Issue 1, pp. 275-284.
  Lang E., Gatidis S., Freise N.F., Bock H., Kubitz R., Lauermann C., Orth H.M., Klindt C., Schuirer M., Keitel V., Reich M., Liu G., Schmidt S., Xu H.G., Qadri S.M., Herebian D., Mayatepek E., Gulbins E., Lang F., Häussinger D., Lang K.S., Foller M., Lang P.A.
  
• Janus kinase 3 regulates renal 25-hydroxyvitamin D 1α-hydroxylase expression, calcitriol formation, and phosphate metabolism. Kidney International, Vol. 87. 2015, Issue 4, pp. 728-737.
  Umbach A.T., Zhang B., Daniel C., Fajol A., Velic A., Hosseinzadeh Z., Bhavsar S.K., Bock C.T., Kandolf R., Pichler B.J., Amann K., Foller M., Lang F.
  
• Enhanced FGF23 production in mice expressing PI3 kinase-insensitive GSK3 is normalized by ßblocker treatment. FASEB Journal, Vol. 30. 2016, No. 2, pp. 994–1001.
  Fajol A., Chen H., Umbach A.T., Quarles L.D., Lang F., Foller M.
  
• NfKB-sensitive Orail expression in the regulation of FGF23 release. Journal of Molecular Medicine, Vol. 94. 2016, Issue 5, pp. 557–566.
  Zhang B., Yan J., Umbach A.T., Fakhri H., Fajol A., Schmidt S., Salker M.S., Chen H., Alexander D., Spichtig D., Daryadel A., Wagner C.A., Foller M., Lang F.