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Pathogenesis of feline infectious peritonitis (B01)

Subject Area Virology
Term from 2013 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 197785619
 
Feline infectious peritonitis (FIP) provides an instructive example of genetic variability being linked to viral pathogenicity. To investigate the molecular basis for the transition from low-pathogenicity (FECV) to high-pathogenicity (FIPV) coronavirus variants, we will characterize recombinant field viruses in vitro and in vivo. First, we will study discriminatory S gene mutations previously identified by comparative sequence analyses of FIPV and FECV isolates. Second, we will investigate the roles of other genetic changes (in S and other genome regions) in FIP development. Third, we will study possible functions of viral accessory proteins (3a, 7a and 7b) in pathogenesis using a range of molecular approaches.
DFG Programme Collaborative Research Centres
Applicant Institution Philipps-Universität Marburg
Co-Applicant Institution Justus-Liebig-Universität Gießen
Project Heads Dr. Gergely Tekes, from 1/2017 until 5/2019; Professor Dr. Heinz-Jürgen Thiel, until 12/2016; Professor Dr. John Ziebuhr
 
 

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