The impact of influenza virus genome variability on host cell kinase networks and the anti-viral response (C01+)

• Subject Area: Virology
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 197785619

The genomic plasticity of Influenza A viruses (IAVs) enables them to quickly adapt to new circumstances and cross species barriers, thus causing epidemics and occasional pandemics. We want to (I) further elucidate in vitro and in vivo the interaction between the host cell factor NF-kB and genetically defined IAVs and (II) identify the IAV factors/functions rendering the virus sensitive to NF-kB inhibition. Part (III) will reveal the functional relevance of IAV-regulated protein kinase signalling networks and of phosphorylations of viral proteins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1021: RNA Viruses: RNA Metabolism, Host Response and Pathogenesis
• Applicant Institution: Philipps-Universität Marburg
• Co-Applicant Institution: Justus-Liebig-Universität Gießen
• Project Heads: Professor Dr. Stephan Pleschka; Professor Dr. M. Lienhard Schmitz