Project Details
Projekt
GRK 1947: Biochemical, Biophysical and Biomedical Effects of Reactive Oxygen and Nitrogen Species on Biological Membranes
Subject Area
Basic Research in Biology and Medicine
Term
from 2014 to 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 231396381
Biological membranes define living cells and determine their interaction with their environment. Reactive oxygen and nitrogen species (ROS/RNS) profoundly affect the physic-chemical properties and thereby the physiological functions of biological membranes.
In an interdisciplinary and interfaculty approach the Research Training Group aims to overcome the traditional boarders between biochemistry, biophysics, medicine, botany and pharmacy. The scientific goal of this Research Training Group is to undertake interdisciplinary and interfaculty based studies of the biochemical, -physical and -medical effects of ROS (including molecular oxygen) and RNS, in biochemical and cellular systems, in order to understand the importance of the interplay between biochemical, biophysical and (patho-) physiological factors, and to discover new interactions of ROS/RNS with biological membranes. The Research Training Group is organised in three intimately linked focus areas with multiple methodological overlap:
(1) production and Membrane-targeting of ROS/RNS,
(2) chemical and physic-chemical effects of ROS/RNS on membranes,
(3) (patho-) physiological consequences of ROS/RNS modified membranes.
The unique feature of this Research Training Group will be that the PhD students will overcome the conventional boarders between biochemistry, biophysics, biology, medicine and pharmacy and learn to work in truly interdisciplinary research groups. Biochemical and biophysical methods of research, along with medical and pharmaceutical approaches will be used to analyse the mechanisms of ROS/RNS production and interaction of ROS/RNS with all constituents of biological membranes, e.g., lipids and proteins (enzymes).
The collaboration of the PhD students within their research projects is promoted by a scheduled teaching programme, which includes for, e.g., thematic workshops and seminars. Additionally, the PhD students is given the opportunity for a research period in another research group and the attendance of national and international conferences. This will contribute substantially to the development of the young scientists knowledge and methodological expertise for best career prospects.
In an interdisciplinary and interfaculty approach the Research Training Group aims to overcome the traditional boarders between biochemistry, biophysics, medicine, botany and pharmacy. The scientific goal of this Research Training Group is to undertake interdisciplinary and interfaculty based studies of the biochemical, -physical and -medical effects of ROS (including molecular oxygen) and RNS, in biochemical and cellular systems, in order to understand the importance of the interplay between biochemical, biophysical and (patho-) physiological factors, and to discover new interactions of ROS/RNS with biological membranes. The Research Training Group is organised in three intimately linked focus areas with multiple methodological overlap:
(1) production and Membrane-targeting of ROS/RNS,
(2) chemical and physic-chemical effects of ROS/RNS on membranes,
(3) (patho-) physiological consequences of ROS/RNS modified membranes.
The unique feature of this Research Training Group will be that the PhD students will overcome the conventional boarders between biochemistry, biophysics, biology, medicine and pharmacy and learn to work in truly interdisciplinary research groups. Biochemical and biophysical methods of research, along with medical and pharmaceutical approaches will be used to analyse the mechanisms of ROS/RNS production and interaction of ROS/RNS with all constituents of biological membranes, e.g., lipids and proteins (enzymes).
The collaboration of the PhD students within their research projects is promoted by a scheduled teaching programme, which includes for, e.g., thematic workshops and seminars. Additionally, the PhD students is given the opportunity for a research period in another research group and the attendance of national and international conferences. This will contribute substantially to the development of the young scientists knowledge and methodological expertise for best career prospects.
DFG Programme
Research Training Groups
Applicant Institution
Universität Greifswald
Spokesperson
Professorin Dr. Christiane A. Helm
Participating Researchers
Professorin Dr. Haike Antelmann; Professor Dr. Uwe T. Bornscheuer; Professor Dr. Gerald Brezesinski; Privatdozentin Dr. Heike Kahlert; Professor Dr. Michael Lalk; Professor Dr. Uwe Lendeckel; Professor Dr. Sigurd Lenzen; Privatdozent Dr. Christopher Horst Lillig; Professorin Dr. Julia Mayerle; Professor Dr. Fritz Scholz; Professorin Dr. Christine Stöhr
