pH-abhängige Aktivierung des Wnt-Signalweges und die Entstehung von Magenkrebs

• Antragsteller: Dr. Peter Walentek
• Fachliche Zuordnung: Pathologie
• Förderung: Förderung von 2012 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 232231485

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Taken together, during my postdoctoral training, I have investigated pH-dependency and post-transcriptional regulation of Wnt signaling and ciliogenesis; expanded the knowledge on ATP4-dependent processes during vertebrate development and human disease; started to investigate the underlying cause of ciliated metaplasia in mice and the role of NHE3 during Xenopus development. During this work, I expanded my skills towards working with mice and adult tissue, as well as human cell culture. Furthermore, I could improve my expertise in Xenopus biology, general molecular and developmental biology, regulation of mucociliary epithelia and motile ciliogenesis, as well as advanced microscopy, genetics and post-transcriptional regulation.

Projektbezogene Publikationen (Auswahl)

• 2014. microRNAs and cilia – An ancient connection. Cell Cycle 13:15, 1–2; August 1, 2014
  Walentek, Peter; Song, Rui & He, Lin
  
• 2014. miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature 510, 115–120
  Song, Rui; Walentek, Peter; Sponer, Nicole; Klimke, Alexander; Lee, Joon Sub; Dixon, Gary; Harland, Richard; Wan, Ying; Lishko, Polina; Lize, Muriel; Kessel, Michael & He, Lin
  
• 2015. The Alternative Splicing Regulator Tra2b Is Required for Somitogenesis and Regulates Splicing of an Inhibitory Wnt11b Isoform. Cell Reports (2015), 10, 1–10. February 3, 2015
  Dichmann, Darwin S.; Walentek, Peter & Harland, Richard M.