pH-abhängige Aktivierung des Wnt-Signalweges und die Entstehung von Magenkrebs

• Antragsteller: Dr. Peter Walentek
• Fachliche Zuordnung: Pathologie
• Förderung: Förderung von 2012 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 232231485

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Taken together, during my postdoctoral training, I have investigated pH-dependency and post-transcriptional regulation of Wnt signaling and ciliogenesis; expanded the knowledge on ATP4-dependent processes during vertebrate development and human disease; started to investigate the underlying cause of ciliated metaplasia in mice and the role of NHE3 during Xenopus development. During this work, I expanded my skills towards working with mice and adult tissue, as well as human cell culture. Furthermore, I could improve my expertise in Xenopus biology, general molecular and developmental biology, regulation of mucociliary epithelia and motile ciliogenesis, as well as advanced microscopy, genetics and post-transcriptional regulation.

Projektbezogene Publikationen (Auswahl)

• 2014. microRNAs and cilia – An ancient connection. Cell Cycle 13:15, 1–2; August 1, 2014
  Walentek, P., Song, R., He, L.
  (Siehe online unter https://doi.org/10.4161/cc.29827)
• 2014. miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110. Nature 510, 115–120
  Song, R., Walentek, P., Sponer, N., Klimke, A., Lee, J.S., Dixon, G., Harland, R., Wan, Y., Lishko, P., Lize, M., Kessel, M., He, L.
  (Siehe online unter https://doi.org/10.1038/nature13413)
• 2015. The Alternative Splicing Regulator Tra2b Is Required for Somitogenesis and Regulates Splicing of an Inhibitory Wnt11b Isoform. Cell Reports (2015), 10, 1–10. February 3, 2015
  Dichmann, D.S., Walentek, P., Harland, R.M.
  (Siehe online unter https://doi.org/10.1016/j.celrep.2014.12.046)