Project Details
Projekt
Revealing cell-to-cell variability in the living mammalian embryo by imaging transcription factor dynamics
Applicant
Dr. Jennifer Zenker
Subject Area
Developmental Biology
Term
from 2013 to 2014
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 232963654
Every organism is composed of various organs which all results from one embryonic cell. Cell division leads to the growing of the embryo. However, it is still highly debated when and how the most primitive cells of the embryo become different from each other in order to form different organs. The Plachta Group recently developed new imaging tools to study the mobility of gene regulatory proteins in live mouse embryos. Using these tools led to the discovery that rather the movement than the amount of such regulatory proteins is crucial for the establishment of different cell fates. The aim of my proposed project is to further understand the molecular mechanism of cell fate determination in living mouse embryos and the identification of important regulatory proteins. Overall, a better understanding how the various organs become determined in the early embryo will help to develop new strategies to repair adult organs under diseases conditions.
DFG Programme
Research Fellowships
International Connection
Australia
