Project Details
Projekt
Structure-function relationships of Hsp47/SERPINH1 and its role in skin fibrosis (B11)
Subject Area
Structural Biology
Term
from 2013 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208
Hsp47 is essential for proper collagen folding and secretion and its upregulation under fibrotic conditions makes it a candidate target for anti-fibrotic drugs. We have characterized its client repertoire and will explore its chaperoning of different clients further. We have studied in detail its mechanism of pH-dependent client binding and release. To investigate its role in normal skin development and fibrosis we have created fibroblast and keratinocyte-specific knockout mouse lines. With potential inhibitors identified in a high-throughput screen we will explore Hsp47’s therapeutic potential in mouse models with skin fibrosis.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität zu Köln
Project Heads
Professor Dr. Ulrich Baumann; Professor Dr. Gerhard Sengle, since 1/2017; Professor Dr. Frank Zaucke, until 12/2016
