Molecular mechanisms of the redox regulation of necroptosis during acute lymphatic leukemia (A21)

• Subject Area: Pediatric and Adolescent Medicine
• Term: from 2013 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463

The project aims at identifying the molecular mechanisms of redox signaling as regulatory principle of signal transduction during necroptosis as alternative mode of programmed cell death in preclinical in vitro and in vivo models of apoptosis-resistant leukemia. The results of the project are expected to open new perspectives for targeted therapeutic interventions in necroptosis signaling and have important implications for various fields of life sciences where defects in cell death programs occur.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 815: Redox-Regulation: Generating Systems and Functional Consequences
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Simone Fulda