TIRF Mikroskop mit FRAP und Hochauflösung

• Subject Area: Basic Research in Biology and Medicine
• Term: Funded in 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 234324669

• Final Report Year: 2017

Final Report Abstract

3D SIM imaging of the foci resulting from the DNA double-strand break repair complex Ku80 was used to show p97 mediates the release of trapped Ku80 rings. In a study of the role that CEACAM1-3S plays in driving melanoma cells into NK mediated cytolysis, SIM imaging was used to resolve the localization of CEACAM isoforms in vesicle-like structures at the sites of cell-cell contact.

Publications

• „CEACAM1-3S drives melanoma cells into NK cellmediated cytolysis and enhances patient survival.“ Cancer Res. 2015
  Ullrich, Nico; Heinemann, Anja; Nilewski, Elena; Scheffrahn, Inka; Klode, Joachim; Scherag, André; Schadendorf, Dirk; Singer, Bernhard B. & Helfrich, Iris
  
• „Sex-Dependent Claudin-1 Expression in the Liver of Euthyroid and Hypothyroid Mice.” Eur Thyroid J. 2015
  Zwanziger, Denise; Rakov, Helena; Engels, Kathrin; Moeller, Lars C. & F�hrer, Dagmar
  
• „Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection.“ Cell Physiol Biochem. 2015
  Merches, Katja; Khairnar, Vishal; Knuschke, Torben; Shaabani, Namir; Honke, Nadine; Duhan, Vikas; Recher, Mike; Navarini, Alexander A.; Hardt, Cornelia; Häussinger, Dieter; Tümmler, Burkhard; Gulbins, Erich; Futerman, Anthony H.; Hoffmann, Daniel; Lang, Florian; Lang, Philipp A.; Westendorf, Astrid M. & Lang, Karl S.
  
• “Age-Dependent Changes of Monocarboxylate Transporter 8 Availability in the Postnatal Murine Retina.“ Front. Cell. Neurosci., 2016
  Henning, Yoshiyuki & Szafranski, Karol
  
• „VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair.“ Mol Cell. 2016 64(1)
  van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori & Meyer, Hemmo
  
• „Biofilm formation of the black yeast-like fungus Exophiala dermatitidis and its susceptibility to antiinfective agents.“ Sci Rep. 2017
  Kirchhoff, Lisa; Olsowski, Maike; Zilmans, Katrin; Dittmer, Silke; Haase, Gerhard; Sedlacek, Ludwig; Steinmann, Eike; Buer, Jan; Rath, Peter-Michael & Steinmann, Joerg
  
• „Neuroendocrine cells of the prostate derive from the neural crest.“ J Biol Chem. 2016
  Szczyrba, Jaroslaw; Niesen, Anne; Wagner, Mathias; Wandernoth, Petra M.; Aumüller, Gerhard & Wennemuth, Gunther