Functional analysis of membrane remodeling by epsin1 (B09)

• Subject Area: Biophysics
• Term: from 2013 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 55908123

The main goal of this project is a molecular understanding of how the endocytic protein epsin1 interacts with membranes and how this protein-membrane interaction affects membrane morphology. Using purified proteins and different model membrane systems the importance of the lipid composition for membrane remodeling will be analyzed. We will study the regulatory effect of known epsin1 interaction partners on membrane deformation, and epsin1 dependent cargo sorting will be reconstituted in vitro to understand key steps of clathrin-mediated endocytosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 803: Functionality Controlled by Organisation in and between Membranes
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Michael Meinecke