Molekulare Grundlagen des verzögerten Alterns bei Säugetieren mit stark divergierenden Alternsraten: Afrikanischen Graumullen Fukomys sp. (Rodentia)
Evolution, Anthropology
Biogerontology and Geriatric Medicine
Final Report Abstract
In summary, our results show that the large lifespan differences between breeders and non-breeders in Fukomys sp. are not caused by globally altered gene expression but presumably by more subtle changes that specifically affect mainly endocrine tissues and selected pathways. Many of the results underline the importance of target genes and concepts that are already heavily examined in aging research including our previous works, e.g. the mTOR-pathway or proteolytic systems. On the other hand, they also reveal interesting contradictions to the current knowledge, e.g. that strong up-regulation of protein synthesis and IGF1 in breeders are compatible with considerable lifespan extensions. We are optimistic that our results will contribute to new, more system-oriented perspectives on prolonging life- and healthspans. In that sense, the concrete genes, expression patterns and contradictions that were identified in this study with regard to lifespan regulation may become be promising targets for follow-up studies.
Publications
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Higher transcriptome stability during aging in long-lived giant mole-rats than in short-lived rats
Sahm A, Bens M, Henning Y, Vole C, Groth M, Schwab M, Platzer M, Szafranski K, Dammann P
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Unusual ratio between free thyroxine and free triiodothyronine in a long-lived mole-rat species with bimodal ageing. PLoS One 9: e113698 (2014)
Henning Y, Vole C, Begall S, Bens M, Broecker-Preuss M, Sahm A, Szafranski K, Burda H, Dammann P
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FRAMA: from RNA-seq data to annotated mRNA assemblies. BMC Genomics 17: 54 (2016)
Bens M, Sahm A, Groth M, Jahn N, Morhart M, Holtze S, Hildebrandt TB, Platzer M, Szafranski K
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Low sulfide levels and a high degree of cystathionine beta-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat. Redox Biol 8: 192-8 (2016)
Dziegelewska M, Holtze S, Vole C, Wachter U, Menzel U, Morhart M, Groth M, Szafranski K, Sahm A, Sponholz C, Dammann P, Huse K, Hildebrandt T, Platzer M
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Outgroups and Positive Selection: The Nothobranchius furzeri Case. Trends Genet 32: 523-5 (2016)
Sahm A, Platzer M, Cellerino A
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Parallel evolution of genes controlling mitonuclear balance in short-lived annual fishes. Aging Cell 16: 488-496 (2017)
Sahm A, Bens M, Platzer M, Cellerino A
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PosiGene: automated and easy-to-use pipeline for genome-wide detection of positively selected genes. Nucleic Acids Res 45: e100 (2017)
Sahm A, Bens M, Platzer M, Szafranski K
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Slow aging in mammals—Lessons from African mole-rats and bats. Semin Cell Dev Biol, 70:154-163 (2017)
Dammann P
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Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. PLoS Genet 14: e1007272 (2018)
Sahm A, Bens M, Szafranski K, Holtze S, Groth M, Gorlach M, Calkhoven C, Muller C, Schwab M, Kraus J, Kestler HA, Cellerino A, Burda H, Hildebrandt T, Dammann P, Platzer M
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Naked mole-rat transcriptome signatures of socially-suppressed sexual maturation and links of reproduction to aging. BMC Biology
Bens M, Szafranski K, Holtze S, Sahm A, Groth M, Kestler HA, Hildebrandt TB, Platzer M
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Retinal S-opsin dominance in Ansell's mole-rats (Fukomys anselli) is a consequence of naturally low serum thyroxine. Sci Rep 8: 4337 (2018)
Henning Y, Mladěnková N, Burda H, Szafranski K, Begall S
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Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging. BMC Biology
Heinze I, Bens M, Calzia E, Holtze S, Dakhovnik O, Sahm A, Kirkpatrick J, Szafranski K, Romanov N, Holzer K, Singer S, Ermolaeva M, Platzer M, Thomas Hildebrandt, Ori A
