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Systems chemistry: new external stimuli, molecular tools and applications

Subject Area Organic Molecular Chemistry - Synthesis and Characterisation
Term from 2014 to 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 239129828
 
Final Report Year 2023

Final Report Abstract

The aim of the project entitled "Systems Chemistry: New External Stimuli, Molecular Tools and Applications" was to give impetus to the research field of "Systems Chemistry", which was still entirely new in 2014. In retrospect, we achieved this aim at all relevant levels. For instance, we were able to establish four new molecular tools for systems chemistry and supramolecular chemistry (orthoester exchange, trithioorthoester exchange, amidinium exchange and trialkoxysilane exchange). With the manipulation of dynamic disulfide systems by ultrasound, we were also able to achieve our goal of establishing a new external stimulus that is of high importance for the field. These research advances are relevant for biomedicine (drug delivery) and for materials science (smart and degradable molecules and polymers). We were able to show, for example, that orthoester cages are suitable for transporting ions through biological membranes (patent published) and can be decomposed in a pH-dependent manner. Likewise, we were able to show that orthoester chemistry is suitable for the production of polymers that are largely similar to well-known polyethylene (PE) plastics, but are much more easily degradable when exposed to water and acid. Our fundamental work on the effect of ultrasound on disulfides has been taken up by multiple research groups dedicated to drug transport and ultrasound-induced release.

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