Eine neue Sicht der postrezeptoralen Signalverarbeitung in retino-genikulärer Sehbahnen beim Menschen.

• Antragsteller: Professor Dr. Jan Kremers
• Fachliche Zuordnung: Augenheilkunde ; Kognitive, systemische und Verhaltensneurobiologie
• Förderung: Förderung von 2013 bis 2021
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 239131698

• Erstellungsjahr: 2017

Zusammenfassung der Projektergebnisse

Spatial and temporal variabilities of L- and M-cone photoreceptor driven ERGs reflecting the activity of retinogeniculate (parvo- and magnocellular-based) and ON/OFF subpathways were established for the human retina using triple silent substitution stimuli. We found that L-cone driven responses were consistently larger than M-cone driven responses across the retina, with full-field L-cone stimulation producing the largest signals. Another key finding was that ERGs reflecting the activity of the two postreceptoral and ON/OFF mechanisms of the L- and M-cone pathways showed distinct spatial arrangements. M-cone driven responses to sawtooth stimuli had the opposite polarity compared to L-cone driven responses particularly for spatially restricted stimuli. The responses measured with sine-wave stimuli at high temporal frequencies, which reflect luminance sensitive magnocellular inputs, strongly depended upon spatial stimulus configuration. In contrast, those measured at low-to-intermediate temporal frequencies, which reflect cone-opponent parvocellular inputs, remained relatively more constant, with L- and M-cone driven responses being more similar in amplitude and approximately in counter-phase.

Projektbezogene Publikationen (Auswahl)

• Incremental and decremental L- and M-cone driven ERG responses: II. Sawtooth stimulation. J Opt Soc Am A (JOSA A) Opt Image Sci Vis 2014;31:A170-178
  Kremers, Jan; Pangeni, Gobinda; Tsaousis, Konstantinos T.; McKeefry, Declan; Murray, Ian J. & Parry, Neil R.A.
  
• Incremental and decremental L- and M-cone-driven ERG responses: I. Square-wave pulse stimulation. JOSA A Opt Image Sci Vis 2014;31:A159-169
  McKeefry, Declan; Kremers, Jan; Kommanapalli, Deepika; Challa, Naveen K.; Murray, Ian J.; Maguire, John & Parry, Neil R. A.
  
• Spatial properties of L- and M-cone driven incremental (On-) and decremental (Off-) ERGs: evidence for the involvement of multiple post-receptoral mechanisms. JOSA A Opt Image Sci Vis 2016;33:A1-11
  Tsai, Tina I.; Jacob, Mellina M.; McKeefry, Declan; Murray, Ian J.; Parry, Neil R. A. & Kremers, Jan
  
• The spatial properties of L- and M-cone inputs to ERGs that reflect different types of post-receptoral processing. PloS one 2015;10:e0121218
  Jacob, Mellina M.; Pangeni, Gobinda; Gomes, Bruno D.; Souza, Givago S.; da Silva Filho, Manoel; Silveira, Luiz Carlos L.; Maguire, John; Parry, Neil R. A.; McKeefry, Declan J. & Kremers, Jan
  
• The influence of stimulus size on heterochromatic modulation ERGs. J Vis 2016;16:13
  Martins, Cristiane Maria Gomes; Tsai, Tina; Barboni, Mirella Telles Salgueiro; da Costa, Marcelo Fernandes; Nagy, Balázs; Ventura, Dora Fix & Kremers, Jan
  
• Towards an ERG assay for studying colour vision in human observers. Doc Ophthalmol 2016;133:109-120
  Kremers, Jan & Bhatt, Deepak