Complexation and adsorption of nanocarriers with biological components like RNA, serum proteins and other blood components and the influence on stability and interaction with cell membranes (Q01)

• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

The goal of TP Q1 is to analyze interactions between nanocarriers and blood components. Molecular deter-minants will be analyzed that lead to enhanced in vivo uptake and improved efficacy of the intended im-munomodulation induced by polymer- and lipid- based NP developed within the SFB1066, with a focus on the protein corona, protein-lipid interactions, and the role of lipids in general. This is done by physico-chemical characterization methods, molecular simulations, and data-driven modelling. The protein corona is analyzed by dynamic light scattering, mass spectrometry, microcalorimetry, and a recently established AF-FFF-based separation technique.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professorin Dr. Katharina Landfester; Professor Dr. Michael Maskos; Professorin Dr. Friederike Schmid