Therapy of primary and secondary liver tumors by addressing tolerance-inducing M2 macrophages using immunomodulating nanoparticles
(B03)
Subject Area
Hematology, Oncology
Term
from 2013 to 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243
M2-type cancer promoting macrophages in the liver cancer microenvironment will be repolarized to cancer suppressing M1-type macrophages using block copolymer-based cationic nanogels. The nanoparticles will be loaded with small molecular drugs, siRNA or antisense oligonucleotides. Targeted delivery and thus a more effective repolarization of M2-macrophages will be further improved by derivatisation of the nanopar-ticles with CD206-binding peptides or nanobodies. For in vivo efficacy testing we have established 3 syn-genic mouse models of hepatocellular carcinoma.
DFG Programme
Collaborative Research Centres
