Transcriptional addressing of dendritic cells (DCs) with the help of an hPFscn1 derived promotor using DC-addressing polymers for tumortherapy (B05)

• Subject Area: Biological and Biomimetic Chemistry
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

This project will develop DNA-vaccines, which are under the translational control of the Fascin-promotor and thus only active in dendritic cells. Since dendritic cells as – non-dividing cells – are rather difficult to transfect, the expertise of E. Wagner and R. Zentel will be combined to develop new, more efficient stimulus responsive transfection systems from blockcopolymers and cationic oligomers.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Co-Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Privatdozent Dr. Matthias Bros; Professor Dr. Ernst Wagner; Professor Dr. Rudolf Zentel