Development and testing of nanoparticles to eliminate the cAMP-mediated immune-suppression in the malignant melanoma (B08)

• Subject Area: Immunology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

We have shown that adenylyl cyclase inhibitor-loaded polypept(o)ide micelles suppress the growth of mela-nomas by repressing intratumoral cAMP formation. In preparation of a clinical trial, the effect of particle-mediated cAMP repression on human melanomas and syngeneic human immune cells will now be investi-gated in the humanized MISTRG mouse melanoma model. We aim to to make micelle-mediated cAMP re-pression by adjuvant nanoparticles even more effective and to identify the involved signal transduction pathways in tumor-infiltrating leukocytes by comparative transcriptome analyses.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Matthias Barz; Privatdozent Dr. Christian Becker; Professor Dr. Tobias Bopp