Molecular characterization of Candida albicans attributes during translocation and dissemination and the effects of immunotherapy (C01)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology ; Immunology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 210879364

Project C1 showed that translocation requires several fungal factors, including the toxin candidalysin. Processing of the candidalysin precursor Ece1 and transcriptional regulation of the ECE1 gene, as well as the virulence (host damage, immunopathology) and avirulence functions (protective immune response) of candidalysin were explored and regulatory networks dissected. C1 will extend its investigations into three aspects: (i) the molecular characterization of the invasive form of C. albicans, (ii) the molecular dissection of C. albicans from translocation to dissemination, and (iii) the impact of immunotherapy on C. albicans colonization, infection, and translocation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 124: Pathogenic Fungi and their Human Host: Networks of Interaction - FungiNet
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Dr. Mark Gresnigt; Professor Dr. Bernhard Hube; Christian Perez, Ph.D., until 6/2021