Modulation of monocytes and B cell functions by humoral immunity in response to Candida albicans (C04)

• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 210879364

C4 aims at elucidating how C. albicans changes the humoral immune response to affect the cellular response, differentiation, polarisation and interaction of effector cells, with a special emphasis on complement and antibodies, and monocytes and B cells, respectively. This includes the detailed analysis of fungal proteins and recruited human complement regulatory proteins (FHR1) and their interaction with monocytes and B cells via distinct receptors. Furthermore, the analysis of B cell populations reacting to C. albicans in reporter mice infected or colonised with C. albicans will give insights into the in vivo immune response to C. albicans.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 124: Pathogenic Fungi and their Human Host: Networks of Interaction - FungiNet
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professorin Dr. Berit Jungnickel; Professor Dr. Stefan Lorkowski, until 6/2017; Professorin Dr. Christine Skerka