Subcortical control of neuronal activity in the hippocampal formation during locomotion (B01)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2013 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 227953431

The Remy group has discovered that a mechanistic coupling of motor signaling and hippocampal theta-oscillations is achieved via a complex circuitry connecting the medial septum and the diagonal Band of Broca with the hippocampus. This circuitry actively controls movement velocity during locomotion, entrains movement-correlated theta oscillations and leads to velocity-adapted membrane potential changes in CA1 principal neurons and neurons of the medial entorhinal cortex. The project will now delve into the functional integration of medial septal neurons into locomotor circuits. It will examine specifically how neuromodulatory projections from the locus coeruleus and the median raphe systemmodulate septo-hippocampal function and behavior.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1089: Synaptic Micronetworks in Health and Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Stefan Remy