Network alterations between hippocampus, entorhinal and prefrontal cortex contributing to spatial working memory impairment under AD-like conditions (C01)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Molecular and Cellular Neurology and Neuropathology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 227953431

This project hypothesizes that the connectivity in the extended hippocampal-prefrontal and entorhinal-prefrontal memory networks is impaired in Alzheimer’s disease models and contributes to spatial working memory deficits. This hypothesis will be examined using analysis of circuit connectivity combined with in vivo multiphoton imaging and optogenetic manipulation in a working memory task.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1089: Synaptic Micronetworks in Health and Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Professor Dr. Martin Fuhrmann; Professorin Dr. Stefanie Poll; Professor Dr. Stefan Remy, until 6/2017