Locus coeruleus – mediated microglial senescence as a driver for tau pathology and neuronal network dysfunction (C02)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells ; Molecular and Cellular Neurology and Neuropathology
• Term: from 2013 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 227953431

Project C02 aims to elucidate if and how the early degeneration of the locus coeruleus (LC) impacts on microglial homeostasis and in particular their senescence, and how this affects neuronal activity in-vivo. Given the role of the latter for neuronal degeneration and in particular tau pathology, the project is likely to identify new targets for intervention in order to prevent functional deficits and neurodegeneration.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1089: Synaptic Micronetworks in Health and Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Head: Professor Dr. Michael Thomas Heneka