Core-multishell nanocarriers for drug delivery into skin (A02)

• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2013 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 234930468

This project aims to develop new water-dispersible CMS nanocarriers for controlled drug delivery and stimuli-controlled release in the skin. It will focus on the one hand on the design, synthesis, characterization, and pharmaceutical application of redox-sensitive CMS architectures based on dendritic polyglycerols. These nanocarriers are especially characterized by their biocompatibility, their defined size in the nanometer range (~10 nm), excellent solubility, and ability to entrap and transport both hydrophilic and hydrophobic drugs with a focus on tacrolimus and tofacitinib. They will respond to redox stimuli, such as oxidative stress and reductive environments by using tailored linker systems.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1112: Nanocarriers: Architecture, Transport and Topical Application of Drugs for Therapeutic Use
• Applicant Institution: Freie Universität Berlin
• Project Head: Professor Dr. Rainer Haag