Project Details
Projekt
Nanocarriers in the skin and oral mucosa of mouse models: Specific targeting of inflammation and role of barrier dysfunctions (C03)
Subject Area
Veterinary Medical Science
Term
from 2013 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 234930468
This project focuses on the in vivo testing of nanocarriers for improved anti-inflammatory drug delivery in the skin and oral mucosa of mice. For the second funding period, the JAK-inhibitor tofacitinib will be investigated in the established atopic dermatitis model. Secondly, triggered release mechanisms, based on an altered redox potential, are investigated. Thirdly, the role of additional barrier alterations as seen in UVB irradiated and chronologically aged mouse skin, partially mimicking alterations typical of skin aging, on the penetration and therapeutic potential of established and novel carriers will be studied. Furthermore, oral mucosa will be tested and a mouse tissue bank from all previous and ongoing animal experiments will be established.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1112:
Nanocarriers: Architecture, Transport and Topical Application of Drugs for Therapeutic Use
Applicant Institution
Freie Universität Berlin
