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Chromatin regulation at promoters and enhancers, a molecular-mechanistic analysis (A02)

Subject Area General Genetics and Functional Genome Biology
Term from 2013 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 213249687
 
Our goal is to understand the regulation of gene expression in Drosophila development, and in particular the interplay between transcription factor activity and chromatin organization. Building on a comprehensive genome-wide analysis of core promoters, we plan to use sensitive proteomics approaches to characterize the interactome of selected general transcription machinery components and histone modifications in a promoter-type specific fashion. In a second aim, we seek to characterize the role of pioneer transcription factors in regulating chromatin accessibility at enhancers within the Ecdysone signaling cascade.
DFG Programme Collaborative Research Centres
Project Head Professorin Dr. Ulrike Gaul (†)
 
 

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