GSC 108:  Hannover Biomedical Research School (HBRS)

• Subject Area: Medicine
• Term: from 2006 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 24390159

• Final Report Year: 2015

Final Report Abstract

In 2000, Hannover Medical School (MHH), one of Germany’s leading medical schools, was the first to establish a structured and accredited interdisciplinary MD/PhD program in Germany. Just three years later, the MHH founded Hannover Biomedical Research School (HBRS) as an “umbrella organization” for existing and future structured postgraduate programs. HBRS currently comprises five international PhD programs – Molecular Medicine (since 2000), Infection Biology and DEWIN (since 2003/ 2010), Regenerative Sciences (from the Excellence Cluster “REBIRTH” in 2007), Auditory Sciences (from the Excellence Cluster “Hearing4all” in 2013) and Epidemiology (since 2013) - one DFG-funded research training group (IRTG 1273 since 2006) as well as the Marie Curie Initial Training Network (ITN-TECAS since 2012). A structured doctoral program for medical students (StrucMed) has also been successfully established in 2005, while a second “Clinical StrucMed” will start in 2015. With the support of the DFG Excellence Initiative, HBRS has become a highly attractive graduate school for (MD)/PhD training with a first-rate international reputation. It co-ordinates teaching and ensures excellent training in high quality research laboratories, and actively encourages integration and interdisciplinary exchange between students and young researchers from medicine, life science and - since 2007 - also with engineering background. HBRS fosters educational and scientific interaction between university and non-university institutions - among these are the Leibniz University of Hannover, the University of Veterinary Medicine Hannover, the Fraunhofer Institute for Toxicology and Experimental Medicine and the Helmholtz Center for Infection Research in Braunschweig. HBRS provides a framework for international guest lectures, summer schools and for the training of talented students for a future career in science. In providing optimal conditions for female PhD students, HBRS aims to motivate and convince female academics to pursue a career in science. With the introduction of a “dual career” concept, involving rotation of positions and tandem research groups, HBRS supports a new model for clinical research scientists. Moreover, HBRS was the spark for a number of additional measures. Thus, in 2011 the MHH initiated the “Voluntary Research Year” for high school graduates, which has been strongly supported by the federal government and has been adopted by many universities and research institutions all over Germany. The “Lower Saxony International Summer Academy in Immunology” (LISA) was also founded in 2011, while in June 2014, the “Young Faculty Program” for senior postdocs (medical doctors and life scientists) was launched.

Link to the final report

http://dx.doi.org/10.2314/GBV:880814004

Publications

• LEF-1 is crucial for neutrophil granulocytopoiesis and its expresssion is severely reduced in congenital neutropenia. Nature Medicine, 2006. 12(10): 1191-7
  Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K, Zeidler C, Lehmann U, Eder M, Baum C, Grosschedl R, Stanulla M, Scherr M. Welte K
  
• Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med. 2006 Mar 20;203(3):519-27
  Worbs T, Bode U, Yan S, Hoffmann MW, Hintzen G, Bernhardt G, Forster R, Pabst O
  
• Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 2006; 38: 1397-1405
  Hinkes B, Wiggins RC, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nürnberg P, Hildebrandt F
  
• Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest 2006; 116: 663-674
  Airik R, Bussen M, Singh MK, Petry M, Kispert A
  
• CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med. 2007 Mar 19;204(3):489-95
  Worbs T, Mempel TR, Bolter J, von Andrian UH, Forster R
  
• Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet. 2007 Jan;39(1):99-105
  Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL
  
• Impaired responsiveness to T-cell receptor stimulation and defective negative selection of thymocytes in CCR7-deficient mice. Blood. 2007 Dec 15;110(13):4351-9
  Davalos-Misslitz AC, Worbs T, Willenzon S, Bernhardt G, Forster R
  
• Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood. 2007 Sep 1;110(5):1519-29
  Reichardt P, Dornbach B, Rong S, Beissert S, Gueler F, Loser K, Gunzer M
  
• Structure of the human receptor tyrosine kinase met in complex with the Listeria invasion protein InlB. Cell. 2007 Jul 27;130(2):235-46
  Niemann HH, Jager V, Butler PJ, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW
  
• Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice. Circulation Research. 2007; 101(11):1104-12
  Kumaravelu Jagavelu, Uwe J.F. Tietge, Matthias Gaestel, Helmut Drexler, Bernhard Schieffer, Udo Bavendiek
  
• The peritoneal micromilieu commits B cells to home to body cavities and the small intestine. Blood. 2007 Jun 1;109(11):4627-34
  Berberich S, Forster R, Pabst O
  
• Helicobacter pylori lipopolysaccharide interacts with TFF1 in a pH-dependent manner. Gastroenterology. 2008 Dec;135(6):2043-54, 2054 e1-2
  Reeves EP, Ali T, Leonard P, Hearty S, O'Kennedy R, May FE, Westley BR, Josenhans C, Rust M, Suerbaum S, Smith A, Drumm B, Clyne M
  
• Novel HAX1 mutations in patients with severe congenital neutropenia reveal isoform-dependent genotype-phenotype associations. Blood. 2008 May 15;111(10):4954-7
  Germeshausen M, Grudzien M, Zeidler C, Abdollahpour H, Yetgin S, Rezaei N, Ballmaier M, Grimbacher B, Welte K, Klein C
  
• Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008 May 1;453(7191):51-5
  Lammermann T, Bader BL, Monkley SJ, Worbs T, Wedlich-Soldner R, Hirsch K, Keller M, Forster R, Critchley DR, Fassler R, Sixt M
  
• Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med. 2008 Oct 27;205(11):2483-90
  Hammerschmidt SI, Ahrendt M, Bode U, Wahl B, Kremmer E, Forster R, Pabst O
  
• Conditional and reversible disruption of essential herpesvirus proteins. Nat Methods. 2009 Aug;6(8):577-9
  Glass M, Busche A, Wagner K, Messerle M, Borst EM
  
• Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest. 2009 Mar;119(3):540-50
  Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U
  
• DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009 May; 113(22):5680-8
  Sörensen I, Adams RH, Gossler A
  
• Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft versus leukemia effects across MHC barriers in full chimeras. Blood 2009 Apr 30;113(18):4440-8
  Ghosh A, Koestner W, Hapke M, Schlaphoff V, Langer F, Baumann R, Koenecke C, Cornberg M, Welte K, Blazar B, Sauer MG
  
• Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression. Proc Natl Acad Sci USA. 2009 Aug 4;106(31):13094-9
  Sjöblom M, *Singh AK, Zheng W, Wang J, Tuo BG, Krabbenhöft A, Riederer B, Gros G, Seidler U
  
• Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection. Hepatology. 2009 Mar; 49(3):781-90
  TrehanPati N, Geffers R, Sukriti, Hissar S, Riese P, Toepfer T, Buer J, Kumar M, Guzmán CA, Sarin SK
  
• Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell. 2009;5(4):434-41
  Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR, Martin U
  
• Guanine nucleotidebinding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity. 2009 May;30(5):708-20
  Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N
  
• High-affinity neurotrophin receptors and ligands promote leukemogenesis. Blood. 2009 Feb 26;113(9):2028-37
  Li Z, Beutel G, Rhein M, Meyer J, Koenecke C, Neumann T, Yang M, Krauter J, von Neuhoff N, Heuser M, Diedrich H, Göhring G, Wilkens L, Schlegelberger B, Ganser A, Baum C
  
• IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes. J Allergy Clin Immunol. 2009; 124(1):81-9
  Wittmann M, Zeitvogel J, Wang D, Werfel T
  
• Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells. J Exp Med. 2009 Nov 23;206(12):2593-601
  Halle S, Dujardin HC, Bakocevic N, Fleige H, Danzer H, Willenzon S, Suezer Y, Hammerling G, Garbi N, Sutter G, Worbs T, Forster R
  
• Induced pluripotent stem cells generated without viral integration. Hepatology. 2009;49(3):1048-9
  Eggenschwiler R, Cantz T
  
• Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor. New England Journal of Medicine. 2009; 361:1-13
  Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hätscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C
  
• Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. J Exp Med. 2009 Oct 26;206(11):2313-20
  Ferch U, Kloo B, Gewies A, Pfander V, Duwel M, Peschel C, Krappmann D, Ruland J
  
• Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med. 2009 Dec 21;206(13):3101-14
  Schulz O, Jaensson E, Persson EK, Liu X, Worbs T, Agace WW, Pabst O
  
• MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells. EMBO J. 2009 May 20;28(10):1392-406
  Schwermann J, Rathinam C, Schubert M, Schumacher S, Noyan F, Koseki H, Kotlyarov A, Klein C, Gaestel M
  
• Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor. Hepatology. 2009 Sep;50(3):799-807
  Hoechst B, Voigtlaender T, Ormandy L, Gamrekelashvili J, Zhao F, Wedemeyer H, Lehner F, Manns MP, Greten TF, Korangy F
  
• Scaffold expulsion and genome packaging trigger stabilization of herpes simplex virus capsids. Proc Natl Acad Sci USA. 2009 Jun 16;106(24):9673-8
  Roos WH, Radtke K, Kniesmeijer E, Geertsema H, Sodeik B, Wuite GJ
  
• STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. Blood 2009; 113(5):1097-104
  Braun A, Gessner JE, Varga-Szabo D, *Syed SN, Konrad S, Stegner D, Vögtle T, Schmidt RE, Nieswandt B
  
• The histamine H4 receptor is functionally expressed on T(H)2 cells. J Allergy Clin Immunol. 2009 Mar;123(3):619-25
  Gutzmer R, Mommert S, Gschwandtner M, Zwingmann K, Stark H, Werfel T
  
• Wang D., Dressel R., Seltsam A., Blasczyk R., Eiz-Vesper B. Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells, Blood 2009; 113(13):3008-16
  Figueiredo C., Wittmann M.
  
• A 96-well-plate-based optical method for the quantitative and qualitative evaluation of Pseudomonas aeruginosa biofilm formation and its application to susceptibility testing. Nat Protoc. 2010 Aug; 5(8):1460-9
  Müsken M, Di Fiore S, Römling U, Häussler S
  
• Blood. 2010 Feb 25;115(8):1481-9
  Song Z, Wang J, Guachalla LM, Terszowski G, Rodewald HR, Ju Z, Rudolph KL
  
• Calcium-modulating cyclophilin ligand does not restrict retrovirus release. Nat Med. 2010 Feb;16(2):155-6
  Kühl A, Münch J, Sauter D, Bertram S, Glowacka I, Steffen I, Specht A, Hofmann H, Schneider H, Behrens G, Pöhlmann S
  
• Cytokine activated NK cells inhibit PMN apoptosis and preserve their functional capacity. Blood. 2010 Aug 26;116(8):1308-16
  Bhatnagar N, Hong HS, Krishnaswamy JK, Haghikia A, Behrens GM, Schmidt RE, Jacobs R
  
• Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity. Blood. 2010 Aug 26;116(8):1308-16
  Bhatnagar N, Hong HS, Krishnaswamy JK, Haghikia A, Behrens GM, Schmidt RE, Jacobs R
  
• Expression patterns of NKG2A, KIR and CD57 define a process of CD56dim NK cell differentiation uncoupled from NK cell education. Blood. 2010 Nov; 116(19):3853-64
  Björkström NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, Björklund AT, Flodström- Tullberg M, Michaëlsson J, Rottenberg ME, Guzmán CA, Ljunggren H-G, Malmberg K-J
  
• gammadelta T cells enhance autoimmunity by restraining regulatory T cell responses via an interleukin-23-dependent mechanism. Immunity. 2010 Sep 24;33(3):351-63
  Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, Heink S, Prinz I, Hemmer B, Kuchroo VK, Oukka M, Korn T
  
• Global genotypephenotype correlations in Pseudomonas aeruginosa. PLoS Pathog. 2010 Aug; 6(8):e1001074
  Pommerenke C, Müsken M, Becker T, Dötsch A, Klawonn F, Häussler S
  
• Inhibition of receptor tyrosine kinases restores immunocompetence and improves immunedependent chemotherapy against experimental leishmaniasis in mice. J Clin Invest. 2010 Apr 1;120(4):1204-16
  Dalton JE, Maroof A, Owens BM, Narang P, Johnson K, Brown N, Rosenquist L, Beattie L, Coles M, Kaye PM
  
• Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology. 2010 May; 138(5):1885-97
  Stegmann KA, Björkström NK, Veber H, Ciesek S, Riese P, Wiegand J, Hadem J, Suneetha PV, Jaroszewicz J, Wang C, Schlaphoff V, Fytili P, Cornberg M, Manns MP, Geffers R, Pietschmann T, Guzmán CA, Ljunggren HG, Wedemeyer H
  
• Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria. Proc Natl Acad Sci U A. 2010 May 11;107(19):8748-53
  Dietrich N, Rohde M, Geffers R, Kroger A, Hauser H, Weiss S, Gekara NO
  
• miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev. 2010 Mar 1;24(5):478-90
  Klusmann JH, Li Z, Böhmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D
  
• miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe. 2010 Oct; 8: 358-68
  Chassin C, Kocur M, Pott J, Duerr CU, Gütle D, Lotz M, Hornef MW
  
• Multiple extrathymic precursors contribute to T-cell development with different kinetics. Blood. 2010;115(6):1137-44
  Saran N, Lyszkiewicz M, Pommerencke J, Witzlau K, Vakilzadeh R, Ballmaier M, von Boehmer H, Krueger A
  
• Neutrophils responsive to endogenous IFN-beta regulate tumor angiogenesis and growth in a mouse tumor model. J Clin Invest. 2010 Apr 1;120(4):1151-64
  Jablonska J, Leschner S, Westphal K, Lienenklaus S, Weiss S
  
• Notch signaling in the immune system. Immunity. 2010 Jan 29;32(1):14-27
  Radtke F, Fasnacht N, Macdonald HR
  
• Oncofetal Fibronectin mRNA Is Highly Abundant in the Blood of Patients with Papillary Thyroid Carcinoma and Correlates with High- Serum Thyroid-Stimulating Hormone Levels. Thyroid 2010; 20, 607-613
  Wehmeier, M., Petrich, T., Brand, K., Lichtinghagen, R., and Hesse, E.
  
• Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI- PLCbeta1 expression is an independent prognostic factor. J Clin Oncol. 2010;28(22):e384-7
  Damm F, Lange K, Heuser M, Oberacker T, Morgan M, Wagner K, Krauter J, Schlegelberger B, Ganser A, Gohring G
  
• Protein transduction from retroviral Gag precursors. Proc Natl Acad Sci USA. 2010 Apr 27;107(17):7805-10
  Voelkel C, Galla M, Maetzig T, Warlich E, Kuehle J, Zychlinski D, Bode J, Cantz T, Schambach A, Baum C
  
• Short Communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21 dependent mechanism. Circ. Res. 2010 Jul 9;107(1):138-43
  Fleissner F, Jazbutyte V, Fiedler J, Gupta SK, Yin X, Xu Q, Galuppo P, Kneitz S, Mary M, Ertl G, Bauersachs J, Thum T
  
• Absence of CD155 aggravates acute graft-versus-host disease. Proc Natl Acad Sci USA. 2011 Mar 8;108(10):E32- 3
  Seth S, Ravens I, Lee CW, Glage S, Bleich A, Forster R, Bernhardt G, Koenecke C
  
• Afferent lymph-derived T cells and dendritic cells use different CCR7-dependent routes for lymph node entry and intranodal migration. Nature Immunol. 2011 Aug 14;12(9):879-87
  Braun A, Worbs T, Moschovakis GL, Halle S, Hoffmann K, Bölter J, Münk A, Förster R
  
• CCR7-mediated LFA-1 functions in T cells are regulated by two independent ADAP/SKAP55-modules. Blood. 2011 Nov 23
  Kliche S, Worbs T, Wang X, Degen J, Patzak I, Meineke B, Togni M, Moser M, Reinhold A, Kiefer F, Freund C, Förster R, Schraven B
  
• Comparision of different miR-21 inhibitor chemistries in a cardiac disease model. J Clin Invest. 2011 Feb 1;121(2): 461-2
  Thum T, Chau N, Bhat B, Gupta SK, Linsley PS, Bauersachs J, Engelhardt S
  
• Completion of Hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines. PLoS Pathog. 2011 Apr; 7(4):e1002029
  Frentzen A, Hüging K, Bitzegeio J, Friesland M, Haid S, Gentzsch J, Hoffmann M, Lindemann D, Zimmer G, Zielecki F, Weber F, Steinmann E, Pietschmann T
  
• Complex c-di-GMP signalling networks mediate the transition between virulence properties and biofilm formation in Salmonella enterica serovar Typhimurium. PLoS One 2011; 6(12):e28351
  Ahmad I, Lamprokostopoulou A, Le Guyon S, Streck E, Barthel M, Peters V, Hardt WD, Römling U
  
• Electrospun cellular microenvironments: Understanding controlled release and scaffold structure. Adv Drug Deliv Rev. 2011;63(4-5):209-20
  Szentivanyi A, Chakradeo T, Zernetsch H, Glasmacher B
  
• Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells. PLoS Biol. 2011;9(7):e1001099
  Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T
  
• Helicobacter pylori genome evolution during human infection. Proc Natl Acad Sci USA. 2011 Mar; 108(12):5033-8
  Kennemann L, Didelot X, Aebischer T, Kuhn S, Drescher B, Droege M, Reinhardt R, Correa P, Meyer TF, Josenhans C, Falush D, Suerbaum S
  
• IFN-λ determines the intestinal epithelial antiviral host defense. Proc Natl Acad Sci USA. 2011 May; 108: 7944-9
  Pott J, Mahlakõiv T, Mordstein M, Duerr CU, Michiels T, Stockinger S, Staeheli P, Hornef MW
  
• Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3(+) Regulatory T Cells in the Lamina Propria. Immunity. 2011 Feb 25;34(2):237-46
  Hadis U, Wahl B, Schulz O, Hardtke-Wolenski M, Schippers A, Wagner N, Müller W, Sparwasser T, Förster R, Pabst O
  
• Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 02/2011; 34(2):237-46
  Hadis U, Wahl B, Schulz O, Hardtke-Wolenski M, Schippers A, Wagner N, Müller W, Sparwasser T, Förster R, Pabst O
  
• Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpldeficient aplastic anemia. Blood 2011 Feb 2 [epub ahead of print]
  Heckl D, Wicke DC, Brugman MH, Meyer J, Schambach A, Büsche G, Ballmaier M, Baum C, Modlich U
  
• Malassezia sympodialis thioredoxin-specific T cells are highly cross-reactive to human thioredoxin in atopic dermatitis. J Allergy Clin Immunol. 2011 Jul;128(1):92-99
  Balaji H, Heratizadeh A, Wichmann K, Niebuhr M, Crameri R, Scheynius A, Werfel T
  
• PD-L1 blockade effectively restores strong graft-versusleukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor geneengineered allogeneic CD8+ T cells. Blood. 2011; 117(3):1030-41
  Koestner W, Hapke M, Herbst J, Klein C, Welte K, Fruehauf J, Flatley A, Vignali DA, Hardtke- Wolenski M, Jaeckel E, Blazar BR, Sauer MG
  
• Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells. Blood. 2011 117:6532-6541
  Hoechst B, Gamrekelashvili J, Manns MP, Greten TF, Korangy F
  
• Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells. Blood. 2011 Mar 17;117(11):3053-64
  Maetzig T, Brugman MH, Bartels S, Heinz N, Kustikova OS, Modlich U, Li Z, Galla M, Schiedlmeier B, Schambach A, Baum C
  
• Prognostic importance of histone methyltransferase MLL5 expression in acute myeloid leukemia. J Clin Oncol. 2011;29(6):682-9
  Damm F, Oberacker T, Thol F, Surdziel E, Wagner K, Chaturvedi A, Morgan M, Bomm K, Gohring G, Lubbert M, Kanz L, Fiedler W, Schlegelberger B, Heil G, Schlenk RF, Dohner K, Dohner H, Krauter J, Ganser A, Heuser M
  
• Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med. 2011 Jan;208(1):13-21
  Björkström NK, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, Michaëlsson J, Malmberg KJ, Klingström J, Ahlm C, Ljunggren HG
  
• Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice. J Clin Invest. 2011 Jul 1
  Hammerschmidt SI, Friedrichsen M, Boelter J, Lyszkiewicz M, Kremmer E, Pabst O, Forster R
  
• WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond. Trends Cell Biol. 2010 Nov;20(11):650-61
  Rottner K, Hanisch J, Campellone KG
  
• Basophils from humans with systemic lupus erythematosus do not express MHC-II. Nat Med 2012; 18(4):488-489
  Dijkstra D, Hennig C, Witte T, Hansen G
  
• Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. Immunity. 2012 Jul 27;37(1):48-59
  Haas JD, Ravens S, Düber S, Sandrock I, Oberdörfer L, Kashani E, Chennupati V, Föhse L, Naumann R, Weiss S, Krueger A, Förster R, Prinz I
  
• Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis. Circ Res. 2012;110(4):530-5
  Napp LC, Augustynik M, Paesler F, Krishnasamy K, Woiterski J, Limbourg A, Bauersachs J, Drexler H, Le Noble F, Limbourg FP
  
• Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med. 2012 Oct;18(10):1550-9
  Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E,Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J,Grosschedl R, Welte K
  
• Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med. 2012;18(10):1550-9
  Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K
  
• Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1+CD11b+F4/80+ regulatory macrophages in mice. Blood. 2012 Apr 26;119(17):3975-86
  Zhang X, Yu S, Hoffmann K, Yu K, Förster R
  
• Recruitment of the tumour suppressor protein p73 by Kaposi's Sarkoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene. 2012 Aug; 32(32):3676-85
  Santag S, Jäger W, Karsten CB, Kati S, Pietrek M, Steinemann D, Sarek G, Ojala PM, Schulz TF
  
• Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34. Proc Natl Acad Sci USA. 2012 Dec 11;109(50):20485-90
  Kasmapour B, Gronow A, Bleck CK, Hong W, Gutierrez MG
  
• Telomere shortening, clonal evolution and disease progression in myelodysplastic syndrome patients with 5q deletion treated with lenalidomide. Leukemia. 2012;26(2):356-8
  Gohring G, Lange K, Hofmann W, Nielsen KV, Hellstrom-Lindberg E, Roy L, Morgan M, Kreipe H, Busche G, Giagounidis A, Schlegelberger B
  
• The phenotype of human STK4 deficiency. Blood. 2012 Apr 12;119(15):3450-7
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