Defining insulin targets in control of feeding-associated reward behaviour (A01)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 222193485

Based on our observations that insulin-dependent activation of MCH-expressing neurons, a heterogeneous population of cells engaging in distinct effector neurocircuits, in obesity contributes to the manifestation of impaired locomotor activity and insulin resistance, and that MCH-neurons project to tanycytes in the median eminence, we aim at deciphering the molecular basis of MCH-neuron heterogeneity and at delineating the functional consequences of MCH neurons acting on tanycytes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 134: Ingestive Behaviour: Homeostasis and Reward
• Applicant Institution: Universität zu Lübeck
• Co-Applicant Institution: Max-Planck-Institut für Stoffwechselforschung
• Project Head: Professor Dr. Jens Claus Brüning