Metabolic modulation of a central reward circuit (A03)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 222193485

To better understand and counteract metabolic disorders such as obesity and type 2 diabetes, strong efforts are being made to define the control mechanisms that regulate body weight and energy homeostasis. Recent studies have shown that noradrenergic locus coeruleus neurons play a critical role in reward-related information processing and we have shown that noradrenalin can directly modulate the homeostatic systems of the hypothalamus. Here we will assess if and how the locus coeruleus neurons are modulated.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 134: Ingestive Behaviour: Homeostasis and Reward
• Applicant Institution: Universität zu Lübeck
• Co-Applicant Institution: Universität zu Köln
• Project Head: Professor Dr. Peter Kloppenburg