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Circadian clocks and hedonic appetite regulation (B01)

Subject Area Endocrinology, Diabetology, Metabolism
Term from 2014 to 2018
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 222193485
 
This project analyses the mechanisms of circadian regulation of homeostatic and reward systems in the context of appetite regulation. We hypothesize that mesolimbic and hypothalamic circadian clocks coordinate hedonic and homeostatic control aspects of appetite regulation and food uptake, respectively. Using genetic and pharmacologic manipulations in mice and human studies, we will analyse the interplay between local clock control at the level of central appetite circuits and systemic circadian endocrine signals such as glucocorticoids and metabolic peptides.
DFG Programme CRC/Transregios
Applicant Institution Universität zu Lübeck
 
 

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