Influence of hepatic lipid profiles on inflammation, fibrogenesis and carcinogenesis in the liver (B07)

• Subject Area: Gastroenterology
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

Our project explores potentially lipid-modulating mechanisms in the progression of hepatic inflammation, injury and fibrosis in chronic non-alcoholic steatohepatitis (NASH) and acute alcoholic steatohepatitis (ASH). Specifically, we will study the hypotheses (1) that, in patients with NASH, specific processing of nutrients produces a disease-specific postprandial plasma lipidome that is relevant for NASH progression, (2) that upregulation of lipoprotein lipase, which is characteristic for NASH, is a compensatory mechanism to inhibit NASH progression and (3) that pharmacological inhibition or genetic deletion of myeloperoxidase attenuates ASH.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Applicant Institution: Universität Hamburg
• Project Head: Privatdozent Dr. Johannes Kluwe