IL-22 and IL-22BP in liver regeneration and carcinogenesis (C08)

• Subject Area: Gastroenterology
• Term: from 2014 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187

Our preliminary and published data indicate that IL-22 has both protective and pathogenic properties in regeneration and carcinogenesis. Thus, strict control of IL-22 is essential. This control is exerted via regulation of IL-22 production and by IL-22BP, an endogenous IL-22 inhibitor. We hypothesize that coordinated expression of IL-22 and IL-22BP in the liver is essential to control the local and temporal effects of IL-22 and thus liver regeneration and carcinogenesis. Our goal is to test this hypothesis using mouse models and to identify the mechanisms regulating IL-22 and IL-22BP.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Samuel Huber