Dendritic dynamics and the perceptual threshold

• Applicant: Professor Matthew Larkum
• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 250048060

• Final Report Year: 2020

Final Report Abstract

This project was, in my opinion, exceptionally successful both in terms of meeting (and even exceeding) the goals laid out in the proposal and in terms of the quality of the publications published in Science and Nature Neuroscience. The final outcome represents a turning point in our understanding of the contribution of dendritic activity to conscious perception.

Publications

• (2016). Active cortical dendrites modulate perception. Science, 354(6319), 1587–1590
  Takahashi, N., Oertner, T. G., Hegemann, P., & Larkum, M. E.
  (See online at https://doi.org/10.1126/science.aah6066)
• (2017). A Reward-Based Behavioral Platform to Measure Neural Activity during Head-Fixed Behavior. Frontiers in Cellular Neuroscience, 11, 156
  Micallef, A. H., Takahashi, N., Larkum, M. E., & Palmer, L. M.
  (See online at https://doi.org/10.3389/fncel.2017.00156)
• (2020) Active dendritic currents gate descending cortical outputs in perception. Nature Neuroscience, 23, 1277-1285
  Takahashi N, Ebner C, Sigl-Glöckner J, Moberg S, Nierwetberg S, Larkum ME
  (See online at https://doi.org/10.1038/s41593-020-0677-8)