Project Details
Projekt
Activation mechanism of the unfolded protein response by lipid bilayer stress (P21)
Subject Area
Biochemistry
Term
from 2014 to 2018
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 57566863
The identity and function of organelles is determined by their protein and lipid composition. Recently, it became obvious that both unfolded proteins and aberrant lipid compositions of the endoplasmic reticulum (ER) membrane are potent activators of a homeostatic program, the unfolded proteins response (UPR). We are studying the most conserved transducer of the UPR, Ire1, and have identified an amphipathic helix that is capable to sense aberrant lipid compositions. Now, we aim at identifying the activation mechanism of Ire1 by lipid bilayer stress in order to define the term "ER-stress" at the molecular level.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professor Dr. Robert Ernst
