GRK 2046:  Parasite Infections: From Experimental Models to Natural Systems

• Subject Area: Microbiology, Virology and Immunology ; Zoology
• Term: from 2015 to 2024
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 251133687

Parasites cause serious, health-depriving, disabling diseases affecting people and animals alike. These pathogens are globally distributed, prevalent, heterogeneous and extremely complex. There is a necessity and growing demand for interdisciplinarily educated, versatile parasitologists. Research in the Research Training Group (RTG) 2046 focuses on four core parasite groups of medical and veterinary importance: Plasmodium, Toxoplasma, Giardia and helminths. The research program emphasizes the study of these parasites in relevant natural hosts and, during the second funding period, focuses on the consequences of co-infections, which are common in natural situations. The research program addresses pressing questions in an exemplary manner on the basis of the focus parasites. These are molecular mechanisms such as drug resistance; parasite intracellular trafficking and intercellular communication crucial for successful habitat formation or metabolic specializations that may lead to new druggable pathways. In addition, cellular aspects are in focus that represent the basis of host immunity and disease pathology and will expand the knowledge base for vaccine development. And finally, organismic aspects are studied to assess parasites’ impact on host populations and their lifetime performance that will generate basic insights into parasite-host ecological relationships. These research topics are part and parcel of the educational concept of RTG 2046 and are essential for training a new generation of parasitologists. The primary training goal is to foster scientists who possess state of the art command of specialty research skills, insightful knowledge of the breadth of parasitology and are well versed in interdisciplinary approaches. This will be achieved by integrating molecular and cellular aspects with organismic perspectives on our four core parasite groups through the research program and the doctoral researchers attending bespoke courses and workshops. Content-related education will be complemented by comprehensive training in soft and transferable skills offered by the local universities’ overarching graduate schools. Equipping next-generation parasitologists with the skills necessary to undertake advanced scientific studies of parasite infections in experimental as well as natural systems is the basic mission of RTG 2046.

• DFG Programme: Research Training Groups
• Applicant Institution: Freie Universität Berlin
• Participating Institution: Charité - Universitätsmedizin Berlin; Humboldt-Universität zu Berlin; Leibniz-Institut für Zoo- und Wildtierforschung (IZW); im Forschungsverbund Berlin e.V.; Max-Planck-Institut für Infektionsbiologie; Max-Planck-Institut für Kolloid- und Grenzflächenforschung; Wissenschaftspark Potsdam-Golm; Robert Koch-Institut (RKI)
• Spokesperson: Professorin Dr. Susanne Hartmann
• Participating Researchers: Dr. Anton Aebischer; Professorin Dr. Friederike Ebner; Dr. Nishith Gupta; Professor Dr. Emanuel Heitlinger, Ph.D.; Professor Dr. Heribert Hofer; Dr. Alyssa Ingmundson; Privatdozent Dr. Jürgen Krücken; Dr. Elena A. Levashina; Professor Dr. Kai Matuschewski; Professor Dr. Frank Mockenhaupt; Dr. Sebastian Rausch; Professor Dr. Georg von Samson-Himmelstjerna; Professor Dr. Frank Seeber; Professor Dr. Peter H. Seeberger; Dr. Bettina Wachter