Role of Ena/VASP proteins in vessel branching and vascular repair (A08)

• Subject Area: Anatomy and Physiology
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 75732319

We have demonstrated an important role of the Ena/VASP proteins in leukocyte-endothelial cell communication, angiogenesis and vascular repair. However, underlying molecular mechanisms and the role of the Ena/VASP proteins in pathologic conditions, such as atherosclerosis, are elusive. Here, we aim to determine the molecular mechanisms and the physiological relevance of Ena/VASP-regulated receptor trafficking and guidance cue signalling in angiogenesis and atherosclerosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 834: Endothelial Signalling and Vascular Repair
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Dr. Peter Benz