Virale Zweckentfremdung des Proteins DDB1 als Evasionsstrategie gegen angeborene Immunität (A07)

• Subject Area: Virology
• Term: from 2014 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 47100475

Project A7 will analyze how chronic viruses counteract IFN responses. Chronic viruses often utilize the DDB1 and Cullin-containing ubiquitin ligase pathway to degrade molecules of the IFN signaling pathway or IFN-induced restriction factors. Also HIV (vpx) and HBV (HBx) proteins exploit this pathway, which will be analyzed in greater detail. Most importantly, the PIs of project A7 use a small molecule inhibitor of the Cullin enzymatic activity that shows high antiviral activity against several viruses. Its therapeutic effect against FV, HIV, HTLV, HCV and HBV will be tested in vitro and if possible in vivo. Furthermore, the antiviral profile of IFNγ will be analyzed in these studies. The group defined a pattern of IFNγ induced and repressed proteins that allows the detailed characterization of their antiviral activity against retroviruses.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 60: Mutual Interaction of Viruses with Cells of the Immune System: From Fundamental Research to Immunotherapy and Vaccination
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Dr. Vu Thuy Khanh Le-Trilling; Professor Dr. Mirko Trilling