Control of cell migration in response to injury by the cancer-associated adhesion molecule EpCAM (A07)

• Subject Area: Nephrology
• Term: from 2014 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

The project will investigate how tubular epithelial cells override collective cell migration (CCM) programs to close a laser-induced injury in the zebrafish pronephros. Of particular interest in this project is the interplay between EpCAM, the CXCR12/CXCR4 signaling module, and the transcriptional regulators MYC and HIC1 in the repair response. Additionally A7 will study the roles of the EpCAM interacting proteins cmtm4 and cmtm6 in CCM and in response to injury, e.g. using transcriptomic approaches of single isolated cells during the migration-dependent repair process.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Gerd Walz