Project Details
Projekt
Influence of FMR1/FMRP expression on female folliculogenesis and ovarian reserve
Applicant
Dr. Julia Rehnitz
Subject Area
Reproductive Medicine, Urology
Term
from 2014 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 253279753
Folliculogenesis and oocyte maturation are underlying multiple genetic and epigenetic regulatory mechanisms. Our research aims the evaluation of genetic and epigenetic influences on the folliculogenesis candidate gene FMR1 (Fragile X Mental Retardation 1). Its protein FMRP is predominantly expressed in granulosa cells within female germline. FMR1 is localized on the X chromosome and includes in its promoter region a base triplet that varies around 30 repeats in general population. Repeats >54 are called premutation. 20% of female premutation carriers are suffering from a POF/POI-(premature ovarian failure/insufficiency) syndrome; but also small CGG repeat deviations from the norm (26
DFG Programme
Research Grants
Co-Investigators
Professor Dr. Thomas Strowitzki; Professor Dr. Peter H. Vogt
