Analysis of P5B ATPase Function

• Applicant: Privatdozent Dr. Eric Lambie
• Subject Area: Developmental Biology ; Cell Biology
• Term: from 2014 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 257149307

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens. PLoS One. 2015 Nov 25;10(11):e0143445
  Lambie EJ, Bruce RD 3rd, Zielich J, Yuen SN
  (See online at https://doi.org/10.1371/journal.pone.0143445)
• Establishment of a CRISPR/Cas9-based strategy for inducible protein dimerization. MicroPubl Biol. 2018 Apr 17. Erratum in: MicroPubl Biol. 2019 Dec 02
  Zielich J, Mangal S, Zanin E, Lambie E
  (See online at https://doi.org/10.17912/w2208r)
• Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans. PLoS One. 2018 Mar 16;13(3):e0194451
  Zielich J, Tzima E, Schröder EA, Jemel F, Conradt B, Lambie EJ
  (See online at https://doi.org/10.1371/journal.pone.0194451)
• Rapamycin-induced proteindimerization as a tool for C. elegans research. MicroPubl Biol. 2018 Mar20. Erratum in: MicroPubl Biol. 2019 Dec 02
  Mangal S, Zielich J, Lambie E, Zanin E
  (See online at https://doi.org/10.17912/w2bh3h)
• ATP13A2 deficiency disrupts lysosomal polyamine export. Nature. 2020 Feb;578(7795):419-424
  van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, Kahler JP, Decuypere JP, Gelders G, Lambie E, Zielich J, Swinnen JV, Annaert W, Agostinis P, Ghesquière B, Verhelst S, Baekelandt V, Eggermont J, Vangheluwe P
  (See online at https://doi.org/10.1038/s41586-020-1968-7)
• ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31198-31207
  Vrijsen S, Besora-Casals L, van Veen S, Zielich J, Van den Haute C, Hamouda NN, Fischer C, Ghesquière B, Tournev I, Agostinis P, Baekelandt V, Eggermont J, Lambie E, Martin S, Vangheluwe P
  (See online at https://doi.org/10.1073/pnas.1922342117)