Computational methods for modeling macromolecular complexes (B09)

• Subject Area: Structural Biology
• Term: from 2014 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 105286809

Project B09 aims to develop (1) inference methods to reconstruct models of structural dynamics from cryo-EM data and (2) computational methods for coarse-grained modeling of macromolecular complexes. To realize aim (1), we will implement various probabilistic models to describe structural dynamics and develop sampling algorithms to infer motion models from 3D and 2D data. To realize aim (2), we will support coarse-grained representations of biomolecular assemblies in our ISD software and develop sampling algorithms for rigid and flexible fitting with hybrid structural data.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 860: Integrative Structural Biology of Dynamic Macromolecular Assemblies
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Michael Habeck