Project Details
Projekt
Impact of virus-induced oscillating stress response on host cell homeostasis and immune response induction (13)
Subject Area
Virology
Term
since 2014
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 240245660
Viral infections activate the integrated stress response, a central signalling pathway controlling protein syn-thesis. This leads to phase separation in the cytosol and the formation of stress granules (SGs), whose possible pro- or anti-viral functions are unclear. By combining time-resolved imaging and quantitative meas-urements, we propose to elucidate how cellular SG and immune responses interplay and influence the maintenance or return of cells to homeostasis. Using the "stress-sensitive" droplet-based microfluidics ap-proach that we previously developed to study SG phase separation, we will investigate the biophysical properties of SG disassembly, a poorly understood aspect of SG dynamics.
DFG Programme
Collaborative Research Centres
Applicant Institution
Ruprecht-Karls-Universität Heidelberg
Project Head
Dr. Alessia Ruggieri, Ph.D.
